Heterochain polymers and IPN chemistry department

Department of linear polymer chemistry (original name – Department heterochain polymers) was established in 1972 on the basis of laboratory hydrazyncontaining polymers. Before April 1999 the department supervised Doctor of Chemistry, professor, honored worker of science and technology A.P. Hrekov, the department is headed by Doctor of Chemistry Yu.V.Savelyev.

The main scientific direction of the department – the development of scientific principles and methods for obtaining polymers in aqueous and organic media .

The department prepared 2 doctors and 21 PhD, has 15 staff members and 4 employee on contract, including 2 doctors of chemical sciences and 6 candidates.

The results are set out in Division 4 monographs, over 535 articles, 108 Certificate of copyright and patents, more than 265 abstracts of reports at national and international conferences, awarded the State Prize of Ukraine on science and technology and Prize L.V. Pisarzhevskii NAS of Ukraine.

The main achievements of department

As a result of years of research in the field of hydrazyncontaining polymers were created new linear polymers with a set of properties that used as multi-purpose film materials.

Conducted fundamental research theoretical foundations of a polyurethane dispersions ionomer with desired properties and the possibility of directional control their physical, chemical and mechanical properties. This allowed for the first time in our country to organize pilot production of polyurethane aqueous dispersions with a wide range of properties. This new perspective direction in polymer chemistry provides a solution to the problem of protecting the environment, organized on the basis of polyurethane dispersions waste technologies, thus ensuring a high level of safety of the process and improve conditions in the workplace.

For the first time conducted survey of fundamental and developed methods for the synthesis of a new type of polyurethane macroheterocyclic fragments in the chain. Found regularities of the processes of such systems and the correlation of their properties with structure. Polyurethane materials based on macroheterocyclic compounds: film coating, water-organic dispersion, polyurethane has ability to complex formation with the metal cations (alkali, alkaline earth and heavy, including radionuclides).

Polyurethanes based on derivatives of hydrazine due mainly of specific physico-chemical and biological properties, capabilities structural and chemical and phase modification, which in turn allows change the location, and availability of biologically active center, is the most attractive among many polymers for use in medical practice.

Due to the modification of polymers or metal-containing additives structural and chemical modification created polyurethanes, which are fungicidal about molds (such as Aspergillus niger et al.) And resistant to biodegradation. Polyurethanes not destrust under the influence of mushrooms and their metabolites, fully inhibit their growth.

On the basis of (macro) heterocyclic compounds created polyurethanes – linear polyurethane and with long-acting bactericidal activity (at least 4 years) against pathogenic bacteria which are the most common causal factors of hospital and postoperative infections: St.aureus, E.coli, Klebsiella pn., Pseud. aeruginosa, Proteus vulgaris.

To solve the problem of disposal of liquid rocket fuel heptyl have the reactive derivatives of hydrazine based heptyl for use as monomers for polymer synthesis and created new water-soluble compounds with bactericidal activity against pathogenic bacteria St.aureus, E.coli, Klebsiella pn. , Pseud. aeruginosa.

It was developed method of basic polyurethane based heptyl and its derivatives in an organic solvent and in the form of aqueous dispersions and polyurethane and multi-purpose polymer materials based on it.

To address the protection from toxic and corrosive action of chamical substances, including strong oxidants developed multilayer polymeric materials with special barrier properties, intended for the manufacture of personal protective goods.

Now a scientific team of the department is working to solve these fundamental problems:

Creating a macro heterocyclic compounds immobilized polymers [including hydroxides soluble poly (meth) acrylic acid copolymer divinylbenzene-styrene and others.] Having selective complexation with metal cations.
Create new multicomponent polymer systems, including nanocomposite systems with a set of specific properties, based polyurethanes hydrazyncontaining linear and branched structures ionomer water despertion polyurethanes, polyurethanes with (macro) and heterocyclic fragments, fillers with activated carbon and layered silicates (poly- and monokationnoho type and organically modified) study of the characteristics of the formation and properties.

As a result of these studies will create a new method and developed new polymeric materials with a set of specific properties, advantages wich is resistant to mechanical stress, elasticity, hydrophobicity, barrier properties and biological activity, mainly multifunctional properties of the polymer matrix. The above properties allow to use these materials in various fields of human activity, including technology, Ecology, biomedytsinskyh and other purposes.

Create new polymer bactericidal and fungicidal compositions and multi-directional vector based polyurethane matrix for transdermal therapeutic systems with prolonged effect.

The purpose of research is to improve the properties of the drugs used in chemotherapy of bacterial infections and diseases that are provoked micromycetae and yeast fungi in particular for increased activity, increased duration, toxicity reduction, overcoming drug resistance of bacteria to antimicrobial agents and mainly providing them with targeted transport .

Based on the model of basic polyurethane polymer compositions are created with anti-bacterial and fungicidal properties as i) hydrophilic polymer system, ii) polyurethane (acrylate) or hydrogels, iii) and polyurethane iiii) polyurethane varnishes.

Applied Research

New technologies and materials are introduced or can be introduced:

The composite polymeric material. Designed for the manufacture of personal protective equipment from aggressive substances.
Polyurethane anion actyve dispersion:
- water printing ink to obtain pore texture with imitation wood;
- binder for impregnating fabrics with aramid fibers;
- soils and pigmented paint coating for dressing skins;
- binder for pigment printing in the textile industry;
- film-forming coatings in removable decontamination from radioactive contamination.
Polyurethane cation actyve dispersion:
- to hydrate offset printing plates in the printing industry;
- binder to produce granulated complex fertilizer of prolonged action.
Printing inks with high strength abrasion.
Nitrocellulose lacquer hardener SKL-1, used for furniture boards that requests are processed.
Polyurethanes having antimicrobial properties.
Foam, with bactericidal and biocompatibility.

List of books

Grekov A.P. Organic chemistry of hydrazine. Kiev: Tekhnika. 1966. 236p.
Grekov A.P., Sukhorukova S.A. Polymers based on hydrazine Kiev: Naukova Dumka. 1976. 216p.
Grekov A.P.,Veselov V.Ya. Physical chemistry of hydrazine Kiev: Naukova Dumka. 1979. 264p.
Grekov A.P., Otroshko G.V. Hydrazinemetry Kiev: Naukova Dumka. 1981. 260p.

List of selected works

Patents

Патент України №33837. МКІ7 C08G 18/08, A61L 15/26, 15/22, 15/16. Спосіб одержання пінополіуретанів, що мають біосумісність та бактерицидність (20-річний) / Л.А. Марковська, О.А. Савельева, Н.А. Галатенко та ін – Опубл. 17.03.2003, Бюл. №3.
Патент України №53729. Спосіб одержання іономірних водорозчинних поліуретанів / В.Я. Веселов, Н.І. Левченко, А.П. Греков – Опубл. 17.02.03, Бюл. №2.
Патент України № 54533, МКІ7 C08G 18/10, 18/28. Спосіб одержання еластичних поліуретанів (20-річний) / В.Я. Веселов, А.П. Греков – Опубл. 17.03.2003, Бюл.№3.
Патент України № 53738. Спосіб одержання бактерицидного препарату (20-річний) / А.П. Греков, А.В. Руденко, О.А. Савельева та ін.- Опубл. 17.02.03, Бюл. №2.
Деклараційний патент України 63092 A. Спосіб одержання поліуретанів / Н.І.Левченко, А.В.Руденко, С.А.Сухорукова та ін.- Опубл. 15.01.2004б Бюл. №1.

Articles

Savelyev Yu.V, Galatenko N.A., Rudenko A.V., Savelyeva O.A. New polyurethane foams: biocompatibility and biological activity // Proc. Nat. Acad. Sci. Ukr., N12 (2001) 127 (in Russian).
Savelyev Yu.V.Investigations of the structure of macromolecular metal chelates based on ionogenic polyurethanes with macroheterocyclic fragments in the chain // Ukr.khim.zhurn, 66, N3 (2000) 43 (in Russian).
Savelyev Yu.V. Polyurethane-Urea Ionomers based on Macrocyclic Polyethers // Polymer & Polymer Composites, 8 (2000) 27.
Georgoussis G., Kanapitsas A., Pissis P., Savelyev Yu.V., Veselov V.Ya., Privalko E.G. Structure-Property relationships in segmented polyurethanes with metal chelates in the main chain // European Polymer Journal, 36 (2000)1113.
Yu.Savelyev, O.Akhranovich, V.Shtompel. Polyurethanes with macroheterocyclic fragments: peculiarities of structure and properties// Vysokomolek.soedin., A, 41, N3 (1999)101 (in Russian).
Georgoussis G., Kyrirsis A., Pissis P., Savelyev Yu.V., et.al. Dielectric studies of molecular mobility and microphase separation in segmented polyurethanes. // European Polymer Jornal., 35 (1999) 2007.
T.Travinska, Yu.S.Lipatov, Yu.V.Maslak, V.F.Rosovitsky. Polyurethane+Polyarlite Latex Mixtures:Synthesis, Characterization and Properties// Polym.Eng.Sci., 39, N3 (1999) 594.
Yu.Savelyev, O.Akhranovich, E.Privalko et.al. Influence of chain-extenders and chain end-groups on properties of segmented polyurethanes.1.Phase morphology// Polymer, 39, N15 (1998) 3425.
Yu.Savelyev, O.Akhranovich, E.Privalko et.al. Influence of chain-extenders and chain end-groups on properties of segmented polyurethanes.II. Dielectric study // Polymer, 39, N15 (1998)3431.
Yu. Savelyev, S.Marushko, N.Kartel. Elastic composite materials “active carbon-poly-urethane”, synthesis and properties// Proc. Nat. Acad. Sci. Ukr., N6 (1998) 158 (in Russian).
Yu. Savelyev. Polyurethanes with biological activity// Proc. Nat. Acad. Sci. Ukr., N7 (1997) 147 (in Russian).
Yu.Savelyev, E.Koval, V.Veselov. Investigation of biological durability of the linear polyurethanes// Ukr.khim.zhurn, 63, N5 (1997)71(in Russian).
V.Privalko, R.Shapoval, Yu.Savelyev, Pissis P. et.al. Influence of chain-extenders and chain end-groups on properties of segmented polyurethanes. Steric immobilization effect// Proc. Nat. Acad. Sci. Ukr., N10 (1997) 153.
V.Privalko, E.Khaehko, Yu.Savelyev. Structure-property relationships for a series of crown ether-containing polyurethane-ureas// Polymer, 34, N8 (1994) 1730.
Sukhorukova S.A., Levchenko N.I., Grekov A.P., Khranovsky V.A. Synthesis and investigation of the anionactive polyurethanes// Vysokomolek.soedin., A, 26, N5 (1982) 932 (in Russian).
Ю.В.Савельев, А.В.Руденко, Л.П.Робота и др. Полимерные материалы, стойкие к биокоррозии: пути создания // Космічна наука і технологія. Додаток. – 2003- Т.9, №2.- С. 24-27.
Ю.В.Савельєв, І.П.Григорюк, С.І.Машковська та ін. Ефективність дії іономерних поліуретанів на фотосинтетичний апарат і продуктивність озимої пшениці за умов посухи //
Науковий вісник Ужгородського національного університету, Серія Біологія.- 2003.- №12, – С.73-81.
В.К.Харитонова, В.Я.Веселов, А.И.Перехрест Полиуретаны на основе несимметричного диметилгидразина // Доповіді НАН України – 2003.- №8 – С.146-150
Е.Р. Ахранович, В.А.Храновский, В.Я.Веселов Поведение полиуретанов с макрогетероциклическими фрагментами в процессах комплексообразования // Высокомол. соед. -2003.- Т.45, № 7. – С. 1078-1084
V.A.Khranovskii, Е.R.Akhranovich, V.Ya.Veselov Poly(urethane)s Based on Crown Ether Derivatives: Study of Spect-ral Effects // Polymer Science. – 2003.- Vol. 45, N1, – P. 1056-1059
В.А.Храновский, В.Я.Веселов, А.П.Греков та ін. Особенности взаимодействия 1,1- диметилгидразина с фенилизоцианатом // Журн.орг.химии – 2003. – Т.39, Вып.1 – С. 105-108
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Ю.С. Липатов, Л.М. Сергеева “Взаимопроникающие полимерные сетки” Изд-во Наукова думка, г. Киев, 1979, 158 с.
Л.М. Сергеева, Л.А. Горбач. Градиентные взаимопроникающие полимерные сетки: получение и свойства. Успехи химии, 1996, Т. 65, № 4, С. 367-376.
Fainleib A., Grigoryeva O., Hourston D. Synthesis of inhomogeneous modified polycyanurates by reactive blending of bisphenol A dicyanate ester and polyoxypropylene glycol. Macromol. Symp., 164, 429-442 (2001).
Fainleib A., Hourston D., Grigoryeva O., Shantalii T., Sergeeva L. Structure development in aromatic polycyanurate networks modified with hydroxyl-terminated polyethers. Polymer, 42, 8361-8372 (2001).
Fainleib A., Kozak N., Grigoryeva O., Nizelskii Yu., Gritsenko V., Pissis P., Boiteux G. Structure-thermal property relationships for polycyanurate-polyurethane linked interpenetrating polymer networks. Polym.Degr.Stab., 76(3), 393-399 (2002).
Lipatov Yu.S., Karabanova L.V. Gradient Interpenetrating Polymer Networks / Ed. D. Klempner, K. Frisch. – / In Advances in Interpenetrating Polymer Networks. – Lancaster: Techomic Publ. Co. – 1994. – Vol. 4. – P. 161-171.
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A.A. Brovko and L.M. Sergeeva. Ionomer-containing Interpenetrating Polymer Networks: Adhesion and Viscoelastic Properties and Structure. In book “Advances in Urethane Ionomers”, Ed. by H.X. Xiao and K. C. Frisch. Vol 1. 1995.
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